Induced pluripotent stem cells (iPSCs) have enormous potential in developmental biology studies and in cellular therapies. 2010; Beltrao-Braga et al. These cell lines showed pluripotency, ability for differentiation to the 3 germ layers, and normal karyotype. In this study, we established 2 human induced pluripotent stem cell lines by expressing reprogramming factors, OCT3/4, SOX2, KLF4, L-MYC, LIN28 and p53 shRNA in the fibroblast skin cells of a patient with Dravet syndrome harboring the Y1102X pathogenic mutation in SCN1A. Creative Biolabs provides IPSC maintenance services and large-scale pluripotent cell production in both 2D and 3D formats. Induced Pluripotent Stem (iPS) cells are mature cells that have been genetically reprogrammed so that they return to their embryonic state. 2011) possibly because they are of mesectodermal origin expressing reprogramming factors inherently (Liu et al. Creative Biolabs is a worldwide leader in cell culture, including inducible cell line generation, and induced pluripotent stem cells culture.

Cell-based therapies currently represent the state of art for tissue regenerative treatment approaches for various diseases and disorders. DPSC could be effectively reprogrammed into induced pluripotent stem cells (iPSC; Yan et al. The discovery of somatic cell nuclear transfer proved that somatic cells can carry the same genetic code as the zygote, and that activating parts of this code are sufficient to re It is not yet known if iPS stem cells and embryonic stem cel Although extensively studied and characterized in human and murine models, iPSCs from animals other than mice lack reproducible results.

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